Join us for the next instalment of the STAGE International Speaker Seminar Series (ISSS) with
Nilanjan Chatterjee
Bloomberg Distinguished Professor
Department of Biostatistics
Bloomberg School of Public Health
Department of Oncology
John Hopkins University School of Medicine
Talk Title:
Complex Model Building for Precision Medicine using Summary-level Information from Big Data Sources
Abstract:
Extraction of information from rich and diverse datasets through summary-level statistics, as opposed to individual level data, can be appealing because of various practical and ethical considerations. In this talk, I will describe statistical methods for building complex models using summary-level information in two distinct applications. One involves assessment of genetic architecture of complex traits by modeling of effect-size distributions using association statistics available from large genome-wide association studies. The other involves development of a generalized meta-analysis framework for unified model building using information on parameters from disparate, but possibly overlapping, sub-models fitted to different studies. Implications for future precision medicine efforts towards disease prevention will be discussed for both applications
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