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Research Connections with Linda Hiraki and Eleanor Pullenayegum
November 24 @ 12:00 pm - 1:00 pm
RESEARCH INSTITUTE SEMINAR SERIES RESEARCH CONNECTIONS
A Research Institute seminar series showcasing successful partnerships between researchers in different research programs or in basic and clinical research. Each seminar highlights the connections that have led to impactful discoveries and stimulate future productivity.
Beyond the t-test: How advanced statistical methods expand understanding of genetics of kidney function in lupus.
Systemic lupus erythematosus (SLE) is a life threatening multisystem autoimmune disease. Lupus nephritis (LN) is one of the most severe manifestations of SLE, affecting up to 75% of SLE patients. Despite evidence that LN clusters in families, and prevalence and severity varies by race/ethnicity, genetic studies of LN risk have not identified susceptibility loci reaching genome-wide significance. This may be due to limitations of cross-sectional study design. No prior LN genetic studies have capitalized on repeated renal measures, nor maximized power by utilizing quantitative renal measures. We are applying statistical methods for longitudinally collected, repeated renal measures of kidney function in children and adults with SLE, to identify genetic determinants of LN.
LINDA HIRAKI, MD, FRCPC, ScD Staff Physician, Division of Rheumatology, Scientist, Genetics & Genome Biology (GGB), SickKids Research Institute; Assistant Professor Pediatrics and Epidemiology, DLSPH, University of Toronto ELEANOR
PULLENAYEGUM, PhD Senior Scientist, Child Health Evaluative Sciences (CHES), SickKids Research Institute; Associate Professor, University of Toronto