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X-WR-CALNAME:CANSSI Ontario STAGE
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BEGIN:VEVENT
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UID:MEC-24aa17e766d29a6954b3deacca4e1bdd@stage.utoronto.ca
DTSTART:20160304T170000Z
DTEND:20160304T180000Z
DTSTAMP:20250624T224400Z
CREATED:20250624
LAST-MODIFIED:20260316
PRIORITY:5
SEQUENCE:114
TRANSP:OPAQUE
SUMMARY:STAGE ISSS: Benjamin Voight
DESCRIPTION:\nJoin us for the next instalment of the STAGE International Speaker Seminar Series (ISSS) with\n\n\n\nBenjamin Voight\n\n\n\nAssistant ProfessorDepartment of Systems Pharmacology and Translational TherapeuticsDepartment of GeneticsPerelman School of MedicineUniversity of Pennsylvania\n\n\n\nTalk Title:\n\n\n\nGenome-Wide Mutation Rates Viewed Through a Seven Nucleotide Window\n\n\n\nAbstract:\n\n\n\nThe rate of single-nucleotide polymorphism varies substantially across the human genome and fundamentally influences evolution and incidence of genetic disease. Previous studies have only considered the immediately flanking nucleotides around a polymorphic site—the site’s trinucleotide sequence context—to study polymorphism levels across the genome. Moreover, the impact of larger sequence contexts has not been fully clarified, even though context substantially influences rates of polymorphism. I will describe a new statistical framework we apply to data from the 1000 Genomes Project to demonstrate that a heptanucleotide (seven nucleotide) context window explains a large fraction of variability in substitution probabilities in the human genome along. We identify new, mutation promoting sequence motifs as well as additional rate variation at sequence contexts known to be highly mutable (CpG sites). I will describe application of our model and computational tools we are developing to interpret human disease genetic studies of de novo mutational burden.\n\n\n\nSpeaker Profile:\n\n\n\nUnavailable\n\n\n\nSpeaker Poster:\n\n\n\n\n\n\n\nBen Voight Poster ( https://stage.utoronto.ca/wp-content/uploads/2025/07/Ben-Voight.pdf )Download\n\n\n\n\n\n\n\nPhotography Disclosure:\n\n\n\nPhotographs and/or video may be taken of participants at STAGE events. These photos/videos are for the Program’s use only and may appear on its website, in printed brochures, or in other promotional or reporting materials. By attending STAGE events, you accept the possibility that you may be videotaped or photographed. If you have any concerns, please inform us by sending an e-mail to esther.berzunza@utoronto.ca\n
URL:https://stage.utoronto.ca/events/stage-isss-benjamin-voight/
ORGANIZER;CN=Anna Goldenberg:MAILTO:
CATEGORIES:CANSSI Ontario STAGE ISSS
LOCATION:1st Floor, Black Wing, 555 University Avenue, Toronto, ON
ATTACH;FMTTYPE=image/png:https://stage.utoronto.ca/wp-content/uploads/2025/06/Voight-Benjamin.png
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