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X-WR-CALNAME:CANSSI Ontario STAGE
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UID:MEC-1f490b64a7d1716e9952d627b9baa45e@stage.utoronto.ca
DTSTART:20170505T160000Z
DTEND:20170505T170000Z
DTSTAMP:20250624T215300Z
CREATED:20250624
LAST-MODIFIED:20260316
PRIORITY:5
SEQUENCE:106
TRANSP:OPAQUE
SUMMARY:STAGE ISSS: Ellen L. Goode
DESCRIPTION:\nJoin us for the next instalment of the STAGE International Speaker Seminar Series (ISSS) with\n\n\n\nEllen L. Goode\n\n\n\nProfessor of EpidemiologyHealth Sciences ResearchMayo Clinic\n\n\n\nTalk Title:\n\n\n\nIntegrative Molecular Epidemiology of Ovarian Cancer\n\n\n\nAbstract:\n\n\n\nEpithelial ovarian cancer is a significant cause of women’s gynecologic morbidity and mortality. It is now thought that the five most common histotypes (high-grade serous, endometrial, clear cell, mucinous, low-grade serous) arise from distinct pre-neoplastic lesions with varied somatic mutation spectrums. While high-penetrance genes (e.g., BRCA1, BRCA2, MLH1, MSH2) are known to contribute to risk, the residual risk associated with family history that is attributable other particular inherited factors remains to be elucidated. Genome-wide association studies (GWAS) within large consortia have identified nearly thirty common variants associated with modest risk of this disease. This seminar will provide an overview of the methods and results from these studies, including genome-wide panels and a series of customized arrays (e.g., iCOGS, OncoArray). In addition, detailed characterization of a subset of cases will be described which demonstrates the power of integrating tumor and germline features, in part, to characterize GWAS-identified loci. As other clinically relevant phenotypes may also be predicted by the genomic features of epithelial ovarian cancers, ideas for further investigation will also be explored. These include the search for rare variants, fine-mapping in non-European populations, and “pan-cancer” genomic analyses. In sum, the genetic epidemiology of epithelial ovarian cancer can serve as a framework for integrative studies of other complex traits.\n\n\n\nSpeaker Profile:\n\n\n\nUnavailable\n\n\n\nSpeaker Poster:\n\n\n\n\n\n\n\nEllen Goode Poster  ( https://stage.utoronto.ca/wp-content/uploads/2025/07/Ellen-Goode_May2017_updated.pdf )Download\n\n\n\n\n\n\n\nPhotography Disclosure:\n\n\n\nPhotographs and/or video may be taken of participants at STAGE events. These photos/videos are for the Program’s use only and may appear on its website, in printed brochures, or in other promotional or reporting materials. By attending STAGE events, you accept the possibility that you may be videotaped or photographed. If you have any concerns, please inform us by sending an e-mail to esther.berzunza@utoronto.ca\n
URL:https://stage.utoronto.ca/events/stage-isss-ellen-goode/
ORGANIZER;CN=CANSSI Ontario:MAILTO:esther.berzunza@utoronto.ca
CATEGORIES:CANSSI Ontario STAGE ISSS
LOCATION:1st Floor, Black Wing, 555 University Avenue, Toronto, ON
ATTACH;FMTTYPE=image/png:https://stage.utoronto.ca/wp-content/uploads/2025/06/Goode-Ellen-L.png
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