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X-ORIGINAL-URL:https://stage.utoronto.ca/
X-WR-CALNAME:CANSSI Ontario STAGE
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UID:MEC-251e16a2aac0ca4847adf561483381bf@stage.utoronto.ca
DTSTART:20160930T160000Z
DTEND:20160930T170000Z
DTSTAMP:20250624T220600Z
CREATED:20250624
LAST-MODIFIED:20260316
PRIORITY:5
SEQUENCE:93
TRANSP:OPAQUE
SUMMARY:STAGE ISSS: Peter Kraft
DESCRIPTION:\nJoin us for the next instalment of the STAGE International Speaker Seminar Series (ISSS) with\n\n\n\nPeter Kraft\n\n\n\nProfessor of Epidemiology and BiostatisticsDirector, Program in Genetic Epidemiology and Statistical GeneticsHarvard T.H Chan School of Public Health\n\n\n\nTalk Title:\n\n\n\nRecent Advances in the Integrative Molecular Epidemiology of Breast Cancer\n\n\n\nAbstract:\n\n\n\nGenome-wide association studies (GWAS) have identified over 94 loci associated \nwith breast cancer (BrCa). However, these explain only 16% of the familial relative \nrisk for BrCa, and the causal mechanisms at these loci remain largely unknown. \nTo identify additional BrCa loci and identify likely causal genes at known loci, an \ninternational consortium recently conducted a GWAS meta-analysis of 119,000 cases \nand 110,000 controls, including 62,000 cases and 46,000 controls genotyped as part \nof the OncoArray network (http://epi.grants.cancer.gov/oncoarray/). I will present \nthe results of this expanded GWAS, with an emphasis on integrative analyses that \ncombine GWAS summary statistics with ancillary data, including eQTL information, \nexperimental DNA-sequence annotation, and summary statistics from GWAS of other \ncancers and cancer-related traits. For example: (1) We leveraged eQTL data across \n45 tissues to conduct a Transcriptome-Wide Association Study (TWAS) of BrCa—\ntesting the association between predicted gene expression levels and risk of BrCa. \nThis TWAS identified twenty-nine novel BrCa loci and highlighted candidate genes \nat known loci. (2) Using summary statistics from GWAS of other cancers, we showed \nthat common variants contribute to shared heritability between BrCa and ovarian, \ncolorectal, lung and prostate cancers. (3) We identified genomic features enriched for \nBrCa-associated markers and used this information to choose candidate markers for \nfollow-up experiments. I will close with a discussion of open statistical problems in \nintegrative molecular epidemiology.\n\n\n\nSpeaker Profile:\n\n\n\nUnavailable\n\n\n\nSpeaker Poster:\n\n\n\n\n\n\n\nPeter Kraft Poster ( https://stage.utoronto.ca/wp-content/uploads/2025/07/Peter-Kraft_STAGE-seminar.pdf )Download\n\n\n\nPhotography Disclosure:\n\n\n\nPhotographs and/or video may be taken of participants at STAGE events. These photos/videos are for the Program’s use only and may appear on its website, in printed brochures, or in other promotional or reporting materials. By attending STAGE events, you accept the possibility that you may be videotaped or photographed. If you have any concerns, please inform us by sending an e-mail to esther.berzunza@utoronto.ca\n
URL:https://stage.utoronto.ca/events/stage-isss-peter-kraft/
ORGANIZER;CN=CANSSI Ontario:MAILTO:esther.berzunza@utoronto.ca
CATEGORIES:CANSSI Ontario STAGE ISSS
LOCATION:11th Floor, 686 Bay Street, Toronto, ON
ATTACH;FMTTYPE=image/png:https://stage.utoronto.ca/wp-content/uploads/2025/06/Kraft-Peter.png
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