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X-WR-CALNAME:CANSSI Ontario STAGE
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DTSTART:20190607T160000Z
DTEND:20190607T170000Z
DTSTAMP:20250624T222700Z
CREATED:20250624
LAST-MODIFIED:20260316
PRIORITY:5
SEQUENCE:72
TRANSP:OPAQUE
SUMMARY:STAGE ISSS: Gil McVean
DESCRIPTION:\nJoin us for the next instalment of the STAGE International Speaker Seminar Series (ISSS) with\n\n\n\nGil McVean\n\n\n\nProfessor of Statistical GeneticsUniversity of OxfordDirector, Oxford’s Big Data Institute\n\n\n\nTalk Title:\n\n\n\nMapping the structure of genetic risk for common disease in the UK Biobank \n\n\n\nAbstract:\n\n\n\nGenetic risk factors frequently affect multiple common human diseases, providing insight into shared pathophysiological pathways and opportunities for therapeutic development.  However, systematic identification of genetic profiles of disease risk is limited by the availability of both comprehensive clinical data on population-scale cohorts and the lack of suitable statistical methodology that can handle the scale of and differential power inherent in multi-phenotype data.  We have developed a disease-agnostic approach to cluster genetic risk profiles for 3,025 genome-wide independent loci across 19,155 ICD-10 diagnostic codes from 320,644 participants in the UK Biobank, representing a large and heterogeneous population.  We identify several hundred distinct disease association profiles and use multiple approaches to link clusters to underlying biological pathways.  We show how clusters can decompose the variance and covariance in risk for disease, thereby identifying underlying biological processes and their impact.  We demonstrate the use of clusters in defining disease relationships and informing therapeutic strategies. \n\n\n\n\n\n\n\nSpeaker Profile:\n\n\n\nProfessor McVean’s research focuses on understanding the molecular and evolutionary processes that shape genetic variation in populations and the relationship between genetic variation and phenotype. He played leading roles in international collaborations to characterize genomic variation, such as the 1000 Genomes Project, helped uncover remarkable processes that drive recombination and mutation in humans, and worked with multidisciplinary teams to discover and characteristic the mechanisms behind genetic drivers of risk to complex disease. He was the founding director of Oxford’s Big Data Institute, is co-founder of the Oxford spinout company, Genomics, and is President of the UK’s Genetics Society. \n\n\n\n\n\n\n\nPhotography Disclosure:\n\n\n\nPhotographs and/or video may be taken of participants at STAGE events. These photos/videos are for the Program’s use only and may appear on its website, in printed brochures, or in other promotional or reporting materials. By attending STAGE events, you accept the possibility that you may be videotaped or photographed. If you have any concerns, please inform us by sending an e-mail to esther.berzunza@utoronto.ca\n
URL:https://stage.utoronto.ca/events/stage-isss-gil-mcvean/
ORGANIZER;CN=CANSSI Ontario:MAILTO:esther.berzunza@utoronto.ca
CATEGORIES:CANSSI Ontario STAGE ISSS
LOCATION:McLaughlin Centre
ATTACH;FMTTYPE=image/png:https://stage.utoronto.ca/wp-content/uploads/2025/06/McVean-Gil.png
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