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X-WR-CALNAME:CANSSI Ontario STAGE
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UID:MEC-8eddb3797212cedc470043e1d3686176@stage.utoronto.ca
DTSTART:20120127T180000Z
DTEND:20120127T190000Z
DTSTAMP:20250719T002100Z
CREATED:20250718
LAST-MODIFIED:20260316
PRIORITY:5
SEQUENCE:183
TRANSP:OPAQUE
SUMMARY:STAGE ISSS: Clarice R. Weinberg
DESCRIPTION:\nJoin us for the next instalment of the STAGE International Speaker Seminar Series (ISSS) with\n\n\n\n Clarice R. Weinberg \n\n\n\nChief, Biostatistics Branch, Division of Intramural Research,National Institute of Environmental Health SciencesNational Institutes of HealthAffiliate Member, UNC Center for Environmental Health and Susceptibility\n\n\n\nTalk Title:\n\n\n\nUsing nuclear families to find genes related to conditions with onset early in life\n\n\n\nAbstract:\n\n\n\nFor complex but rare conditions, such as birth defects, where genetic variants confer a fairly small relative increase in risk, pedigree-based linkage studies have limited ability to localize risk-relevant genes. For such conditions, geneticists  can use other approaches, such as family-based or population-based association studies. This talk will introduce some approaches to association mapping. Likelihood-based methods of analysis based on genotyping affected individuals and their parents, as a “triad,” allow for use of standard software, permit estimation of relative risks, provide robustness against bias due to self-selective recruitment and population stratification, and allow for extensions that can account for missing parental genotypes, for maternally-mediated genetic effects, and for parent-of-origin effects. If time permits, extensions to quantitative traits and gene-by-environment effects will be explored, together with an extension of the design to include an  unaffected sibling, which produces a tetrad and enables estimation of main effects  of exposures.\n\n\n\nSpeaker Profile:\n\n\n\nDr. Weinberg earned her Ph.D. in Biomathematics from the University  of Washington in Seattle in 1980. After serving on the faculty of the Department of Biostatistics in Seattle for two years, she came to the biostatistics group at  NIEHS in 1983, where she has headed up the Biostatistics Branch since 1997. She was elected Fellow of the American Statistical Association in 1995, and is on the editorial board of Environmental Health Perspectives and serves as statistical  editor for the American Journal of Epidemiology. She holds adjunct professorships  in both the Department of Epidemiology and the Department of Biostatistics at the  School of Public Health at UNC, and has coauthored more than 200 peer-reviewed  publications. She delivered the distinguished Greenberg lectureship in Biostatistics  at the UNC School of Public Health in 1998, and was awarded both the Nathan Mantel award and the Janet Norwood award in 2005 for her contributions to statistical epidemiology and genetics. Her current research interests are in statistical  methods related to the design and analysis of studies in epidemiology, statistical genetics as applied to family-based studies of qualitative and quantitative traits, and  data mining for analysis of high-dimensional data. \n\n\n\nSpeaker Poster:\n\n\n\n\n\n\n\nClarice Weinberg Poster ( https://stage.utoronto.ca/wp-content/uploads/2025/07/ISSS-Poster-Weinberg-Clarice.pdf )Download\n\n\n\nPhotography Disclosure:\n\n\n\nPhotographs and/or video may be taken of participants at STAGE events. These photos/videos are for the Program’s use only and may appear on its website, in printed brochures, or in other promotional or reporting materials. By attending STAGE events, you accept the possibility that you may be videotaped or photographed. If you have any concerns, please inform us by sending an e-mail to esther.berzunza@utoronto.ca\n
URL:https://stage.utoronto.ca/events/stage-isss-clarice-weinberg/
ORGANIZER;CN=CANSSI Ontario:MAILTO:esther.berzunza@utoronto.ca
CATEGORIES:CANSSI Ontario STAGE ISSS
LOCATION:4th Floor, Elm Wing, 555 University Ave, Toronto, ON
ATTACH;FMTTYPE=image/png:https://stage.utoronto.ca/wp-content/uploads/2025/07/Weinberg_Clarice.png
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