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X-WR-CALNAME:CANSSI Ontario STAGE
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UID:MEC-7a1bb1ae4894617e33fe25166afca9d9@stage.utoronto.ca
DTSTART:20140502T160000Z
DTEND:20140502T170000Z
DTSTAMP:20250721T183100Z
CREATED:20250721
LAST-MODIFIED:20260316
PRIORITY:5
SEQUENCE:129
TRANSP:OPAQUE
SUMMARY:STAGE ISSS: Frank Dudbridge
DESCRIPTION:\nJoin us for the next instalment of the STAGE International Speaker Seminar Series (ISSS) with\n\n\n\nFrank Dudbridge \n\n\n\nProfessor of Statistical Genetics, Department of Non-communicable Disease Epidemiology, London School of Hygiene and Tropical Medicine\n\n\n\nTalk Title:\n\n\n\nExplaining heritability and predicting risk with polygenic scores  \n\n\n\nAbstract:\n\n\n\nIt is now accepted that much of the heritability of complex traits can be found on current genotyping products, but most of the genetic variants that affect the traits are not statistically significant. Polygenic scores, formed by summing risk alleles over thousands of markers, offer a simple yet effective way to access this missing heritability. I review applications of polygenic scores to establish a polygenic effect, demonstrate a shared genetic basis for related traits, predict individual disease risks, and infer causal effects using Mendelian randomization. I give a theoretical analysis of the method and use it to show that samples of tens to hundreds of thousands of subjects are needed to create risk predictors that are clinically useful. With the growth of national biobanks and international consortia, such sample sizes are beginning to become feasible. I show how polygenic scores allow simple methods for estimating the heritability explained by a genotyping chip, the number of markers with effects on the trait, and the genetic correlation between related traits. This approach gives similar results to more advanced but computationally intensive methods. Examples from Psychiatric and cancer datasets are presented.\n\n\n\nSpeaker Profile:\n\n\n\nFrank Dudbridge trained in mathematics at Kings College London and Imperial College London. After an early career in image processing he moved into statistical genetics through postdoctoral appointments at the University of Oxford and University of Cambridge. He was a senior statistician at the MRC Biostatistics Unit, Cambridge from 2004-2009 before moving to the London School of Hygiene and Tropical Medicine where is currently Professor of Statistical Genetics and Director of the Bloomsbury Centre for Genetic Epidemiology and Statistics. His interests are in statistical methods in genetic epidemiology, in which has made important contributions to the analysis of family-based association studies, genome-wide association scans and Mendelian randomisation designs. He has developed widely used software including the UNPHASED package for genetic association analysis with missing data. He collaborates with multiple groups in the areas of cardiovascular, cancer, psychiatric and endocrinological genetics. His research is funded by the MRC, EC, NIH, ESRC and Breast Cancer Campaign. He is an associate editor of the Journal of the Royal Statistical Society (C), Human Heredity and BMC Bioinformatics, is on the editorial board of Molecular Autism, and has served as associate editor of Bioinformatics.\n\n\n\nSpeaker Poster:\n\n\n\n\n\n\n\nFrank Dudbridge Poster ( https://stage.utoronto.ca/wp-content/uploads/2025/07/Dudbridge-Frank-Poster.pdf )Download\n\n\n\nPhotography Disclosure:\n\n\n\nPhotographs and/or video may be taken of participants at STAGE events. These photos/videos are for the Program’s use only and may appear on its website, in printed brochures, or in other promotional or reporting materials. By attending STAGE events, you accept the possibility that you may be videotaped or photographed. If you have any concerns, please inform us by sending an e-mail to esther.berzunza@utoronto.ca\n
URL:https://stage.utoronto.ca/events/stage-isss-frank-dudbridge/
ORGANIZER;CN=CANSSI Ontario:MAILTO:esther.berzunza@utoronto.ca
CATEGORIES:CANSSI Ontario STAGE ISSS
LOCATION:4th Floor, Elm Wing, 555 University Ave, Toronto, ON
ATTACH;FMTTYPE=image/png:https://stage.utoronto.ca/wp-content/uploads/2025/07/frank_dudbridge.png
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