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X-WR-CALNAME:CANSSI Ontario STAGE
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DTSTART:20160603T160000Z
DTEND:20160603T170000Z
DTSTAMP:20250624T224800Z
CREATED:20250624
LAST-MODIFIED:20260316
PRIORITY:5
SEQUENCE:74
TRANSP:OPAQUE
SUMMARY:STAGE ISSS: Shili Lin
DESCRIPTION:\nJoin us for the next instalment of the STAGE International Speaker Seminar Series (ISSS) with\n\n\n\nShili Lin\n\n\n\nProfessor of Statistics, College of Arts and SciencesProfessor of Biostatistics, College of Public Health Visiting Professor, Mathematical Biosciences Institute Ohio State University\n\n\n\nTalk Title:\n\n\n\nAddressing the Correlated Feature in Sequencing-Based DNA MethylationData for Detection of Differentially Methylated Regions \n\n\n\nAbstract:\n\n\n\nDNA methylation is an epigenetic change occurring in genomic CpG\nsequences that contribute to the regulation of gene transcription both \nin normal and malignant cells. In recent years, aided by fast parallel\nsequencing technology, a number of genome-wide platforms have been\ndeveloped to provide high throughput DNA methylation data. They can \nbe classifed as bisulfte-based (BS-seq) or capture-based (Cap-seq), \nboth producing a massive amount of data. Numerous sophisticated \nstatistical methods have been developed to analyze both types of data, \nbut methods for BS-seq data are mainly for detecting diferentially \nmethylated loci (DMLs), although diferentially methylated regions (DMRs) \nare often of more relevance biologically. The most prominent feature \nthat is often overlooked in DML detection methods is the correlation in \nmethylation signals in neighboring CpG sites. In this talk, I will discuss \nseveral statistical methods for analyzing both BS-seq and Cap-seq data \nfor detecting DMRs between two groups. In particular, I will highlight\nmethods that take correlations into consideration and provide confdence\nbounds of DMRs\n\n\n\nSpeaker Profile:\n\n\n\nUnavailable\n\n\n\nSpeaker Poster:\n\n\n\n\n\n\n\nShili Lin Poster ( https://stage.utoronto.ca/wp-content/uploads/2025/07/Shili-Lin-Poster.pdf )Download\n\n\n\nPhotography Disclosure:\n\n\n\nPhotographs and/or video may be taken of participants at STAGE events. These photos/videos are for the Program’s use only and may appear on its website, in printed brochures, or in other promotional or reporting materials. By attending STAGE events, you accept the possibility that you may be videotaped or photographed. If you have any concerns, please inform us by sending an e-mail to esther.berzunza@utoronto.ca\n
URL:https://stage.utoronto.ca/events/stage-isss-shili-lin/
ORGANIZER;CN=CANSSI Ontario:MAILTO:esther.berzunza@utoronto.ca
CATEGORIES:CANSSI Ontario STAGE ISSS
LOCATION:1st Floor, Black Wing, 555 University Avenue, Toronto, ON
ATTACH;FMTTYPE=image/png:https://stage.utoronto.ca/wp-content/uploads/2025/06/Lin-Shili.png
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